Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency

Abstract

Cell signaling underlies transcriptional and/or epigenetic control of a vast majority of cell fate decisions during early embryonic development. Yet, the sequence of molecular and signaling events underlying pre- to post-implantation epiblast differentiation remains poorly understood. Through comprehensive mapping of the proteome, phosphoproteome, transcriptome, and epigenome of embryonic stem cells transitioning from naive to primed pluripotency, Yang et al. shed new insights on the multi-layered control of the phased progression of pluripotency.