Studies On The Oxidative Addition Of N,N-Dimethylamine To Bromojuglones And Bromomethyljuglones

Abstract

The nucleophilic addition of dimethylamine to bromojuglones and bromomethyljuglones is followed by elimination of hydrogen bromide or oxidation. With 2-bromojuglone, the oxidative process predominates at low temperature. The regiochemistry of the addition is a function of the temperature and of the position of the bromine atom (C-2 or C-3) on the quinone. © 1994, The Pharmaceutical Society of Japan. All rights reserved.