Acylated flavonol glycoside from Platanus orientalis

Abstract

The ethylacetate and n-butanol fractions of ethanolic extract of Platanus orientalis leaves led to the isolation of new acylated flavonol glycoside as 3′,5,7-trihydroxy-4′-methoxyflavonol 3-[O-2-O-(2,4-Dihydroxy)-E- cinnamoyl-α-l-rhamnopyranosyl-(1 → 6)-β-d-glucopyranosyl (1 → 2)]-β-d-glucopyranoside, along with seven known compounds. All the compounds were characterized by NMR including 2D NMR techniques. The isolates were evaluated for NF-κB, nitric oxide (NO), aromatase and QR2 chemoprevention activities and some of them appeared to be modestly active.