Four new phenones from the cortexes of Polygala tenuifolia

Abstract

From the 95% EtOH extract of the cortexes of Polygala tenuifolia, four new phenones and three known xanthones were isolated. The structures of the four new phenones were identified as 4-O-[α-L-rhamnopyranosyl-(1→2)-β-D- glucopyranosyl]-2-hydroxyl-6-methoxybenzophenone (tenuiphenone A, 1), 3,5-di-C-β-glucopyranosyl-2,4,6,3′-tetrahydroxybenzophenone (tenuiphenone B, 2), 2′,4′,6′-trihydroxyphenyl-(24Z)- triacontene-1-one (tenuiphenone C, 3), 2′,4′,6′- trihydroxyphenyl-(26Z)-dotriacontene-1-one (tenuiphenone D, 4) respectively, on the basis of spectroscopic analyses. The isolation of 1 and 2 supplied an evidence for the hypothesis that xanthone was biosynthesized from benzophenone in the plants. © 2005 Pharmaceutical Society of Japan.