Imobilisasi Propanolol HCl Pada Hidrogel Poli(Vinil Alkohol) - Natrium Alginat Dengan Teknik Radiasi

Abstract

IMMOBILIZATION OF PROPANOLOL HCL IN POLY(VINYL ALCOHOL) - SODIUM ALGINATE HYDROGEL USING IRRADIATION TECHNIQUE. The aim of this work is to use hydrogels for drug immobilization matrix prepared by gamma irradiation technique for controlled release of the drug. Immobilization of propanolol HCl in poly(vinyl alcohol) (PVA)-sodium alginate (NaAlg) hydrogels have been carried out. The solution mixtures of PVA-NaAlg (5/0.5, wt %) containing different content of propanolol HCl (8 mg to 16 mg) were freeze-thawing for three cycles and then irradiated at various doses (10 kGy to 30 kGy) by gamma radiation. The chemical changes of hydrogels were characterized using Fourier Transform-Infra Red (FT-IR) and morphologies of hydrogels were investigated using Scanning Electron Microscope (SEM). The released of propanolol HCl were tested in aqueous solutions using UV-Vis spectrophotometer at 37 °C in buffer phosphate (pH 6.8). After evaluated it was found that with increasing irradiation doses up to 30 kGy and the gel fraction increased. In contrast, water absorption decreased as well as the cumulative amount of drug decrease. SEM observation of hydrogel PVA-g-NaAlg surfaces showed a large heterogeneous porous and can be a candidate as a matrix for drug release controlled..