Assessment of thrombospondin-1 level in type II diabetic patients

Abstract

The study is intended to asses serum levels of Thrombospondin-1, fasting blood glucose in type 2 diabetic patients, also correlation between Thrombospondin-1 in both males and females. The study was conducted on randomly selected 65 type 2 diabetic patients (34 males and 31 females) attending the diabetes mellitus center in Al-Sadder Teaching City in Al- Najaf province, Iraqi and a group of 24 apparently healthy subjects (12 Males and 12 Females) were included as a control group . The Study was carried out from August 2013 to February 2014.The patients' age was ranging from 35 to 64 years old. The results indicated a significant increase (p < 0.05) in serum FBG and TSP-1 levels in diabetic patients in comparing with healthy groups. The results also revealed no significant differences (p > 0.05) in serum TSP-1 levels between males and females in both patients and healthy groups, while the results of FBG levels significantly (p < 0.05) increase in females than males in both patients and healthy groups. The results have been shown significant positive correlation (P < 0.05) between TSP-1 and FBG in (males and females), males, females DM patients. The present study concluded that Thrombospondin-1 were marker for detection and diagnosis of diabetic patients type 2.