Libraries via Metathesis of Internal Olefins

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Abstract

The cross-metathesis of internal olefins is applied for the combinatorial synthesis of small organic molecules; this reaction is conveniently carried out in neat olefin (oleic-acid derivatives) and requires only 0.001 equiv. of [Ru(CHPh)Cl2(PCy3)2] as catalyst (Cy = cyclohexyl).

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Brändli, C., & Ward, T. R. (1998). Libraries via Metathesis of Internal Olefins. Helvetica Chimica Acta, 81(9), 1616–1621. https://doi.org/10.1002/(SICI)1522-2675(19980909)81:9<1616::AID-HLCA1616>3.0.CO;2-P

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