Prognostic Value of Phase Angle Changes for Functional Recovery and Nutritional Status in Patients With Intestinal Failure

Abstract

Objective: To investigate the relationship between phase angle (PhA) changes and daily activity ability, skeletal muscle mass, and grip strength in patients with intestinal failure. Methods: We enrolled 170 patients with intestinal failure, divided into a PhA increase group (n = 85) and a PhA decrease group (n = 85). General information was compared between the two groups. Bioelectrical impedance analysis was used to measure PhA, skeletal muscle mass index (SMI), and grip strength. The Functional Independence Measure (FIM) score was recorded at admission and discharge, and the changes of each indicator were calculated. T-test, chi-square test, Pearson correlation analysis, and multivariate linear regression analysis were performed to explore the relationship between PhA changes and prognosis. Results: Compared with the PhA decrease group, patients in the PhA increase group had larger changes in FIM (20 (18, 23) vs. 13 (12, 15)), SMI (0.21 (−0.49, 0.89) kg/m2 vs. −0.28 (−1.51, 0.60) kg/m2), and grip strength (3.10 (1.95, 4.30) kg vs. 0.90 (0.50, 1.20) kg) (p < 0.05). Multivariate regression analysis showed that PhA change was an independent influencing factor for FIM change (β = 0.816, p = 0.002) and SMI change (β = 0.270, p = 0.046). Admission PhA was negatively correlated with PhA change (r = −0.803, p < 0.001). Conclusion: PhA change is closely related to the daily activity ability and skeletal muscle mass of patients with intestinal failure and can be used as an objective indicator for assessing nutritional status and prognosis. Clinically, attention should be paid to the dynamic changes of patients’ PhA, and targeted nutritional support and rehabilitation measures should be adopted to improve prognosis.