Obesity-Associated GNAS Mutations and the Melanocortin Pathway

Edson Mendes de Oliveira; Julia M. Keogh; Fleur Talbot; Elana Henning; Rachel Ahmed; Aliki Perdikari; Rebecca Bounds; Natalia Wasiluk; Vikram Ayinampudi; Inês Barroso; Jacek Mokrosiński; Deepthi Jyothish; Sharon Lim; Sanjay Gupta; Melanie Kershaw; Cristina Matei; Praveen Partha; Tabitha Randell; Antoinette McAulay; Louise C. Wilson; Tim Cheetham; Elizabeth C. Crowne; Peter Clayton; I. Sadaf Farooqi

Journal ArticleOPEN ACCESS

Obesity-Associated GNAS Mutations and the Melanocortin Pathway

Mendes de Oliveira E
Keogh J
Talbot F
et al.

New England Journal of Medicine (2021) 385(17) 1581-1592

DOI: 10.1056/nejmoa2103329

77Citations

100Readers

Abstract

Abstract Background GNAS encodes the Gαs (stimulatory G-protein alpha subunit) protein, which mediates G protein–coupled receptor (GPCR) signaling. GNAS mutations cause developmental delay, short s...

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APA

Mendes de Oliveira, E., Keogh, J. M., Talbot, F., Henning, E., Ahmed, R., Perdikari, A., … Farooqi, I. S. (2021). Obesity-Associated GNAS Mutations and the Melanocortin Pathway. New England Journal of Medicine, 385(17), 1581–1592. https://doi.org/10.1056/nejmoa2103329

Obesity-Associated GNAS Mutations and the Melanocortin Pathway

Abstract

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