Neoaustin: A meroterpene produced by Penicillium sp.

Abstract

The title meroterpene neoaustin {systematic name: (1′S,2′R,3S, 7′R,9′S,11′S,12′R)-11′-hydr-oxy-2,2,2′, 9′,12′-penta-methyl-6′,15′-dimethyl-ene-2, 6-dihydro-13′-oxaspiro-[pyran-3,5′-tetra-cyclo-[7.5.1.0 1,11.02,7]penta-deca-ne]-6,10′,14′-trione}, Cl25H30O6, comprises five rings, three six-membered and two five-membered. The absolute configuration was established based on [D] = +166.91° (c 1.21, CH2Cl2). In the crystal, the mol-ecules are connected into a supra-molecular helical chain via O - H⋯O hydrogen bonds reinforced by C - H⋯O contacts.