Effects of anaesthetic induction on myocardial function and metabolism: a comparison of fentanyl, sufentanil and alfentanil

Abstract

Anaesthetic induction may induce myocardial ischaemia. A prospective randomized trial was instituted to compare the effect on ventricular function and myocardial metabolism of induction with fentanyl (FEN) or its analogues sufentanil (SUF) or alfentanil (ALF) in 96 patients undergoing elective coronary artery bypass grafting (CABG). Haemodynamic, metabolic (coronary sinus oxygen and lactate extraction) and gated ventrìculo graphic measurements were made awake pre-induction (PRE), after induction (IND) and after intubation (INT). Induction was performed with FEN 75 μg · kg-1 SUF 15 μg · kg-1 or ALF 125 μg · kg-1 and metocurine. Fentanyl induction was associated with the greatest stability of mean arterial pressure (MAP), cardiac performance, and systolic function without associated myocardial lactate production. SUF produced the greatest depression of systolic function (p < 0.05) but without haemodynamic instability or myocardial lactate production in all but one patient. Induction with ALF produced the greatest reduction in MAP (p < 0.05) associated with the greatest decrease in diastolic compliance (p < 0.05) and 50 per cent incidence of myocardial lactate production (p < 0.05) with no significant change in coronary blood flow or myocardial oxygen consumption. © 1988 Canadian Anesthesiologists.