A protein-interaction array inside a living cell

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Abstract

Taking the bait: Protein-interaction arrays were generated in living cells by the interaction of bait-presenting artificial receptor constructs (bait-PARCs) with micrometer-scaled antibody surface patterns (see figure). This method was applied to simultaneously monitor the interaction kinetics of a prey protein with two distinct bait proteins in individual living cells. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Gandor, S., Reisewitz, S., Venkatachalapathy, M., Arrabito, G., Reibner, M., Schröder, H., … Dehmelt, L. (2013). A protein-interaction array inside a living cell. Angewandte Chemie - International Edition, 52(18), 4790–4794. https://doi.org/10.1002/anie.201209127

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