Abstract
Background The (pro)renin receptor [(P)RR] is implicated in the pathogenesis of cardiovascular disease. We investigated the effects of (P)RR blockade after myocardial infarction (MI) in a mouse coronary-ligation model. Methods and Results Mice underwent sham control surgeries (n = 8) or induction of MI followed by 28 days' treatment with a vehicle control (n = 8) or (P)RR antagonist (n = 8). Compared with sham control subjects, MI + vehicle mice demonstrated reduced left ventricular (LV) ejection fraction (LVEF: P
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Ellmers, L. J., Rademaker, M. T., Charles, C. J., Yandle, T. G., & Richards, A. M. (2016). (Pro)renin Receptor Blockade Ameliorates Cardiac Injury and Remodeling and Improves Function after Myocardial Infarction. Journal of Cardiac Failure, 22(1), 64–72. https://doi.org/10.1016/j.cardfail.2015.08.341
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