Effect of timing of staged percutaneous coronary intervention on clinical outcomes in patients with acute coronary syndromes

Abstract

BACKGROUND: Complete revascularization reduces cardiovascular events in patients with acute coronary syndromes (ACSs) and multivessel disease. The optimal time point of non– target-vessel percutaneous coronary intervention (PCI) remains a matter of debate. The aim of this study was to investigate the impact of early (<4 weeks) versus late (≥4 weeks) staged PCI of non– target-vessels in patients with ACS scheduled for staged PCI after hospital discharge. METHODS AND RESULTS: All patients with ACS undergoing planned staged PCI from 2009 to 2017 at Bern University Hospital, Switzerland, were analyzed. Patients with cardiogenic shock, in-hospital staged PCI, staged cardiac surgery, and multiple staged PCIs were excluded. The primary end point was all-cause death, recurrent myocardial infarction and urgent premature non– target-vessel PCI. Of 8657 patients with ACS, staged revascularization was planned in 1764 patients, of whom 1432 patients fulfilled the eligibility criteria. At 1 year, there were no significant differences in the crude or adjusted rates of the primary end point (7.8% early versus 10.8% late, hazard ratio [HR], 0.72 [95% CI, 0.47–1.10], P=0.129; adjusted HR, 0.80 [95% CI, 0.50–1.28], P=0.346) and its individual components (all-cause death: 1.5% versus 2.9%, HR, 0.52 [95% CI, 0.20–1.33], P=0.170; adjusted HR, 0.62 [95% CI, 0.23–1.67], P=0.343; recurrent myocardial infarction: 4.2% versus 4.4%, HR, 0.97 [95% CI, 0.475–1.10], P=0.924; adjusted HR, 1.03 [95% CI, 0.53– 2.01], P=0.935; non– target-vessel PCI, 3.9% versus 5.7%, HR, 0.97 [95% CI, 0.53–1.80], P=0.928; adjusted HR, 1.19 [95% CI, 0.61– 2.34], P=0.609). CONCLUSIONS: In this single-center cohort study of patients with ACS scheduled to undergo staged PCI after hospital discharge, early (<4 weeks) versus late (≥4 weeks) staged PCI was associated with a similar rate of major adverse cardiac events at 1 year follow-up. REGISTRATION: URL: https://www.clini​caltr​ials.gov; Unique identifier: NCT02241291.