Reversible dilated cardiomyopathy related to amphotericin B therapy

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Abstract

We describe a patient who developed dilated cardiomyopathy and clinical congestive heart failure after 2 months of therapy with amphotericin B (AmB) for disseminated coccidioidomycosis. His echocardiographic abnormalities and heart failure resolved after posaconazole was substituted for AmB. It is important to recognize the rare and potentially reversible toxicity of AmB.

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Danaher, P. J., Cao, M. K., Anstead, G. M., Dolan, M. J., & DeWitt, C. C. (2004). Reversible dilated cardiomyopathy related to amphotericin B therapy. Journal of Antimicrobial Chemotherapy, 53(1), 115–117. https://doi.org/10.1093/jac/dkg472

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