The construction of dual-emissive ratiometric fluorescent probes based on fluorescent nanoparticles for the detection of metal ions and small molecules

Abstract

With the rapid development of fluorescent nanoparticles (FNPs), such as CDs, QDs, and MOFs, the construction of FNP-based probes has played a key role in improving chemical sensors. Ratiometric fluorescent probes exhibit distinct advantages, such as resistance to environmental interference and achieving visualization. Thus, FNP-based dual-emission ratiometric fluorescent probes (DRFPs) have rapidly developed in the field of metal ion and small molecule detection in the past few years. In this review, firstly we introduce the fluorescence sensing mechanisms; then, we focus on the strategies for the fabrication of DRFPs, including hybrid FNPs, single FNPs with intrinsic dual emission and target-induced new emission, and DRFPs based on auxiliary nanoparticles. In the section on hybrid FNPs, methods to assemble two types of FNPs, such as chemical bonding, electrostatic interaction, core satellite or core-shell structures, coordination, and encapsulation, are introduced. In the section on single FNPs with intrinsic dual emission, methods for the design of dual-emission CDs, QDs, and MOFs are discussed. Regarding target-induced new emission, sensitization, coordination, hydrogen bonding, and chemical reaction induced new emissions are discussed. Furthermore, in the section on DRFPs based on auxiliary nanoparticles, auxiliary nanomaterials with the inner filter effect and enzyme mimicking activity are discussed. Finally, the existing challenges and an outlook on the future of DRFP are presented. We sincerely hope that this review will contribute to the quick understanding and exploration of DRFPs by researchers.