RNA Delivery: A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes (Adv. Mater. 12/2020)

Abstract

In article number 1906128, Dan Peer and co‐workers describe the design and synthesis of novel ionizable lipids based on a linker strategy. The lipids are formulated into lipid nanoparticles and are screened for their gene silencing efficacies in cell‐culture models in vitro. Potent lipids are identified and analyzed for in vivo gene silencing efficacy in murine primary lymphocytes. Furthermore, no liver toxicity and no potential immune activation are observed in mice.