Novel Piperazine Derivatives as Anti Microbial Agents: A Comprehensive Review

Abstract

Over the past decade, there has been an increased development of resistance in organisms that are typical pathogenic in humans. This increased resistance has limited the selection of antimicrobials that may be used to treat specific organisms. Therefore, there is demanding to develop novel classes of drugs, with fewer side effects, and shorter lengths of treatment are key in continuing the fight against infectious disease. In the search of newer antimicrobial agents, various heterocyclic compounds have been examined and out of them, Piperazine derivatives have exhibited diverse biological activities such as antibacterial, antifungal, antitubercular, anticancer, antiviral, and antioxidant activities. In this work, we provide a summary of the recent advances of Piperazine derivatives exhibits anti-microbial activity and significant information of piperazine derivatives which may assist in the drug design and development of potent antimicrobial agents.