The relation between the sensitization to molecular components of inhalant allergens and food reactions in patients suffering from atopic dermatitis

Abstract

To evaluate the relation between the sensitization to molecular components of inhalant allergens and the occurrence of food reactions in atopic dermatitis patients. Another aim is to evaluate the semi-quantification results of the ISAC Multiplex testing to reveal the relevance of the leading allergens. The complete dermatological and allergological examination including the examination of the sensitization to molecular components with Multiplex ISAC testing was performed. The food reactions to examined food allergens were confirmed in the open exposure test (history). Altogether 100 atopic dermatitis patients were examined–48 men, 52 women, the average age 40.9 years. The leading molecular components are cysteine protease (Der f 1, Der p 1), NPC2 protease (Der f 2, Der p 2), Acidic glycoprotein (Alt a 1), PR 10 proteins (Bet v 1, Mal d 1, Aln g 1 and Cor 1.04), lipocalins (Can f 1, Fel d 4, Mus m 1, Equ c 1), uteroglobulin (Fel d 1), Kallikrein (Can f 5) and molecular components of Timothy and Bermuda grass (glycoprotein). The significantly higher occurrence of sensitization to molecular components Aln g 1, Bet v 1, Phl p 1, 2, 4, 5, 6, 11 was confirmed in patients suffering from reactions to peanuts, hazelnuts, celery, apple and peach.