Clinical application of a novel diagnostic scheme including pancreatic β-cell dysfunction for traumatic multiple organ dysfunction syndrome

Abstract

A novel diagnostic scheme that includes pancreatic β-cell dysfunction analysis for the diagnosis of traumatic multiple organ dysfunction syndrome (MODS) was investigated to assist in the early diagnosis and detection of MODS. Early intervention and treatment of MODS has been associated with a reduced mortality rate. A total of 2,876 trauma patients (including patients post-major surgery) were admitted to the intensive care unit of the authors' hospital between December 2010 and December 2015 and enrolled in the present study. There were 205 cases where the patient succumbed to their injuries. In addition to the conventional diagnostic scheme for traumatic MODS, indexes of pancreatic β -cell dysfunction [fasting blood-glucose (FBG), homeo-static model assessment-β and (blood insulin concentration 30 min following glucose loading-fasting insulin concentra-tion)/(blood glucose concentration 30 min following glucose loading-FBG concentration)] were included to establish an improved diagnostic scheme for traumatic MODS. The novel scheme was subsequently used in clinical practice alongside the conventional scheme and its effect was evaluated. The novel scheme had a significantly higher positive number of MODS diagnoses for all trauma patients compared with the conventional scheme (12.48 vs. 8.87%; P<0.01). No significant.