Abstract
Some spiro[piperidine-4,2′(1′H)-quinazolin]-4′(3′H) -ones 3 and spiro[piperidine-4,5′(6′H)-[1,2,4]triazolo-1,5-c] quinazolines] 4 were synthesized and evaluated as ligands of the nociceptin receptor. The examined compounds showed partial agonistic activity, except compounds 3, 4n that proved to be pure antagonists. © 2006 Pharmaceutical Society of Japan.
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Mustazza, C., Borioni, A., Sestili, I., Sbraccia, M., Rodomonte, A., Ferretti, R., & Del Giudice, M. R. (2006). Synthesis and evaluation as NOP ligands of some spiro[piperidine-4, 2′(1′H)-quinazolin]-4′(3′H)-ones and spiro[piperidine-4,5′(6′H)-[1,2,4]triazolo[1,5-c]quinazolines]. Chemical and Pharmaceutical Bulletin, 54(5), 611–622. https://doi.org/10.1248/cpb.54.611
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