Which hemogram parameter is more cautionary in euthyroid patients with gestational diabetes mellitus

Abstract

Gestational Diabetes Mellitus is the most diagnosed metabolic disease in pregnancy. The mother and fetus are affected both adversely for this disorder. Gestational Diabetes pathogenesis is associated with subchronic inflammation. The aim of this study was to compare the various hemogram parameters in euthyroid patients with Gestational Diabetes Mellitus and healthy pregnant controls and to determine which parameter is more cautionary for Gestational Diabetes Mellitus diagnosis. This study was conducted in the Endocrinology Department of Van Training and Research Regional Hospital and Obstetrics and Gynecology Department of Private Lokman Heki̇m Van Hospital. The 53 GDM patients and 35 healthy pregnant women, whose gestational age were higher than twenty four weeks and whose euthyroid, normotansive were included in the study. Statistically significant relationships between platelet count (PC), platelet distribution width (PDW), lymphocyte count (LC), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), red cell distribution width (RDW) and GDM disease were found (p; 0.000, 0.000,0.000, 0.000, 0.000, 0.007 respectively). Platelet distribution width had higher sensitivity and specificity than other parameters. Although platelet distribution width is a less known or an unconsidered parameter in complete blood count, it gives more precise information than other hemogram parameteres. It may be convenient to screen the gestational diabetes as an adjunct to oral glucose tolerance test.