Amyloidogenic peptide homologous to fragment 129-148 of human myocilin

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Abstract

Myocilin is a protein with a molecular weight near 50 kDa. It is expressed in almost all organs and tissues.1 We showed that the peptide DQLETQTR ELETA YSNLLRD corresponding to N-terminal leucine zipper motif (LZM) of the protein is able to form amyloid-like fibrils. The possible role of this motif in myocilin aggregation is discussed. © 2013 Landes Bioscience.

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Egorov, V. V., Grudinina, N. A., Lebedev, D. V., Shaldzhyan, A. A., Slita, A. V., Sirotkin, A. K., … Shavlovsky, M. M. (2013). Amyloidogenic peptide homologous to fragment 129-148 of human myocilin. Prion, 7(3), 248–253. https://doi.org/10.4161/pri.24239

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