Garlic oil alleviates high triglyceride levels in alcohol-exposed rats by inhibiting liver oxidative stress and regulating the intestinal barrier and intestinal flora

Abstract

Garlic oil (GO) is a kind of natural extract extracted from garlic, which has strong antioxidant activity. This study elucidates the protective mechanism of GO against alcohol-induced high triglyceride levels. Sixty male Sprague Dawley rats were assigned to five groups, including a control group (CON), a model group (MOD) treated with alcohol 56% v/v at 8 ml kg−1 day−1 for 2 weeks then 10 ml kg−1 day−1 for 8 weeks, a low-dose GO group (GO-L) given GO at 20 mg kg−1 day−1, a high-dose GO group (GO-H) given GO at 40 mg kg−1 day−1, and a positive group (POS) given diammonium glycyrrhizinate at 200 mg kg−1 day−1. The results showed that GO could significantly reduce the serum and liver triglyceride levels caused by alcohol exposure (p