Mutagenicity of the halogenated olefin, 2 bromo 2 chloro 1, 1 difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane

Abstract

The presumed halothane metabolite, 2-bromo-2-chloro-1, 1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtilis transformation assay to score the production of mutagenic lesions in transforming DNA.