P-aminoacetophenonic acids produced by a mangrove endophyte streptomyces sp. (strain HK10552)

Abstract

Four new p-aminoacetophenonic acids, named (2E)-11-(4'-aminophenyl)-5, 9dihydroxy-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (1), 9-(4'-aminophenyl)-3, 7dihydroxy-2,4,6-trimethyl-9-oxo-nonoic acid (2), (2E)-11-(4'-aminophenyl)-5,9- O-cyclo4,6,8-trimethyl-11-oxo-undec-2-enoic acid (3) and 9-(4'-aminophenyl)-3,7- O-cyclo-2,4,6trimethyl-9-oxo-nonoic acid (4), were isolated from an endophyte Streptomyces sp. (strain HK10552) of the mangrove plant Aegiceras corniculatum. The structures of 1-4 were elucidated by using spectroscopic analyses. The relative stereoconfigurations of compounds 3 and 4 were determined by NOESY experiments. In the bioassay test, 1-4 showed no cytotoxicity against the Hela cell lines. Compound 4 also showed no inhibitory bioactivity on HCV protease and SecA ATPase and wasn't active against VSVG/HIV-luc pseudotyping virus. Copyright © 2010 by the authors.