Clinical Characteristics in Non-Insulin-Dependent Diabetic Patients with Long Duration in Japan: Relation to Risk Factors for Vascular Complications

Abstract

Onuma, T., Tsutsui, M., Uehara, 0., Masuda, M., Kikuchi, T., Ishigame, M., Suzuki, K. and Takebe, K. Clinical Characteristics in Non-Insulin-Dependent Diabetic Patients with Long Duration in Japan—Relation to Risk Factors for Vascular Complications. Tohoku J. Exp. Med., 1994, 172 (4), 369-374 —In this study, we evaluated the control state of body weight, blood pressure, and blood glucose during the recent 10 years in 82 patients of non-insulin-dependent diabetes mellitus (NIDDM) who had long duration of diabetes for 20-25 years without ischemic heart disease (IHD) and diabetic nephropathy (Neph). The patients without either IHD or Neph showed significantly lower incidences of obese (11 vs. 40%, p<0.05), hypertensive (0 vs. 20%, p<0.05) and poor glycemic control state (7 vs. 27%, p<0.05) for 10 years than the patients with IHD alone, and showed significantly lower incidences of hypertensive (0 vs. 20%, p<0.05) and poor glycemic control state (7 vs. 33%, p<0.01) than the patients with Neph alone. The control state of body weight was similar between the patients without either IHD or Neph and with Neph alone. In addition, the patients without either IHD or Neph showed significantly lower incidences of obese (11 vs. 56%, p<0.01) and hypertensive control state (0 vs. 40%, p<0.01) for 10 years than the patients with both IHD and Neph. The control state of blood glucose was similar between the two groups. These results suggest that for long survival of NIDDM patients without development or progression of IHD and Neph, non-obese and nonhypertensive state as well as good glycemic control should be maintained for long time.—diabetes mellitus; ischemic heart disease; nephropathy; hypertension. © 1994, Tohoku University Medical Press. All rights reserved.