EyeXNet: Enhancing Abnormality Detection and Diagnosis via Eye-Tracking and X-ray Fusion

Abstract

Integrating eye gaze data with chest X-ray images in deep learning (DL) has led to contradictory conclusions in the literature. Some authors assert that eye gaze data can enhance prediction accuracy, while others consider eye tracking irrelevant for predictive tasks. We argue that this disagreement lies in how researchers process eye-tracking data as most remain agnostic to the human component and apply the data directly to DL models without proper preprocessing. We present EyeXNet, a multimodal DL architecture that combines images and radiologists’ fixation masks to predict abnormality locations in chest X-rays. We focus on fixation maps during reporting moments as radiologists are more likely to focus on regions with abnormalities and provide more targeted regions to the predictive models. Our analysis compares radiologist fixations in both silent and reporting moments, revealing that more targeted and focused fixations occur during reporting. Our results show that integrating the fixation masks in a multimodal DL architecture outperformed the baseline model in five out of eight experiments regarding average Recall and six out of eight regarding average Precision. Incorporating fixation masks representing radiologists’ classification patterns in a multimodal DL architecture benefits lesion detection in chest X-ray (CXR) images, particularly when there is a strong correlation between fixation masks and generated proposal regions. This highlights the potential of leveraging fixation masks to enhance multimodal DL architectures for CXR image analysis. This work represents a first step towards human-centered DL, moving away from traditional data-driven and human-agnostic approaches.