PHYSIOLOGICAL EFFECTS OF TURMERIC (Curcuma longa L) IN THE FORM OF NANO AND CRUDE EXTRACT

Abstract

Turmeric (Curcuma longa L.) is well-known as a medicinal plant with many physiological effects on the human body. This study compares the physiological effects of nano-extract and crude turmeric extract on blood, kidney, liver, and blood serum. The phytochemical was qualitatively screened using thin-layer chromatography. The antioxidant capacity was evaluated through the 2,2-diphenyl-1-picrylhydrazyl method. In this study, 45 Mus musculus were divided into nine groups, each comprising five Mus musculus. The first group was the control group to compare the group given the nano extract and the crude extract (group C). The other 40 musculus were divided into two large groups, where four groups were given nano extract with various doses (group N). The other four groups were given crude extract with varying quantities (Group E). The dose variation between the nano and the crude extract is the same. For example, N1 and E1 are given 500 mg/kg bw, and N2 and E2 are given 1000 mg/kg bw. Then up to N4 and E4 with an increase of 500 mg/kg bw. The results show that the nano-extract's inhibitory concentration antioxidant activity was 9.87 μg/mL, more than the ethanol extract (64.39 μg/mL). In addition, the nano-extract significantly increased the number of blood cells and improved the liver's physiology to an average level. The conclusion that can be drawn here is that the efficacy of nano extracts was better than crude extracts in improving the physiological effects.