Synthesis, identification and study of the anti-microbial activity of novel Chalcone and epoxy Chalcone compounds

Abstract

In this study, new chalcone and epoxy chalcone synthesized by condensation of 4-acetylbiphenyl with the appropriate aldehydes. The epoxy chalcone prepared via the reaction chalcone with alkaline hydrogen peroxide in methanol. We characterized their mass spectra and 1H, 13C-NMR, and 2D-HSQC spectra to confirm their structure and absolute configuration. The target compounds were then screened for their potential antibacterial and antifungal activities. Most of the tested chalcone compounds had better activity against the fungal strains Fusarium and Aspergillus Niger.