Abstract
Nature has designed nanosized particles, specifically viruses, equipped to deliver cargo to cells. We report the chemical bioconjugation and shape shifting of a hollow, rod-shaped tobacco mosaic virus (TMV) to dense spherical nanoparticles (SNPs). We describe methods to transform TMV rods to spheres, load TMV rods and spheres with the chemotherapeutic drug, doxorubicin (DOX), to deliver modified particles to breast cancer cells, and to determine the IC50 values of the plant virus-based drug delivery system.
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Bruckman, M. A., Czapar, A. E., & Steinmetz, N. F. (2018). Drug-loaded plant-virus based nanoparticles for cancer drug delivery. In Methods in Molecular Biology (Vol. 1776, pp. 425–436). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7808-3_28
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