Evaluation of Antioxidant Activity of Natural Products

Abstract

The methods for evaluating antioxidant property of natural products in in vitro and in vivo lipid peroxidation systems are reviewed. Antioxidant activity of tocopherols, caro-tenoids, flavonoids and curcuminoids have been demonstrated against lipid peroxidation induced in microsomes, erythrocytes, plasma lipoproteins and in animal trials. Recently, in vivo antioxi-dant function of natural products was extensively investigated in humans together with explanation of their absorbability and metabolic fate. 1 ‚Í ‚ ¶ ‚ß ‚É ‰ä •' ‚Å‚Í •½‹Ï Žõ-½‚Ì •L'· ‚É"º ‚Á ‚Ä,"®-¬•d ‰» ‚â 's •ð, ƒKƒ"‚È ‚ǂ̘V‰»‚ǂ̘V‰» •« Ž¾ •a ‚É'Î ‚· ‚é-\-h‚É'å ‚«‚È‹»-¡ ‚ª Ž• ‚½ ‚ê‚Ä‚¢ ‚é•B‚± ‚Ì ‚ae‚¤‚È•a‹C ‚Ì-\-h‚É‚Í,"ú •í ‚Ì •H• ¶ Šˆ‚ÌŠˆ‚Ì ‰e ‹¿ ‚ª 'å ‚« ‚- ,-Î ‰© •F-ì•Ø‚â‰Ê •¨ ‚Ì •ÛŽae‚Ì-L OEø •« ‚ª,'½ ‚-‚Ì ‰u Šw'² •¸ ‚©‚ç-¾‚ç‚©‚É ‚³ ‚ê ‚Ä‚« ‚Ä‚¢ ‚é1)•`4)•B-ì •Ø ‚â ‰Ê •¨ ‚É ‚Í,•u •R Ž_‰» •¬ •ª •v ‚ª "ä Šr "I '½ ‚-ŠÜ‚Ü‚ê ‚Ä‚¨ ‚è,•H •i ‚AE‚µ‚Ä•ÛŽae‚µ‚½•RŽ_‰» •¨ Ž¿‚ª,ƒq ƒg ‚Ì 'Ì "à ‚Å•a ‹C‚Ì OE´ˆö ‚ɂȂ銈•‚ɂȂ銈•« Ž_'f ‚â ƒ‰ ƒW ƒJƒ‹ ‚Ì •Á‹Ž ‚É-ð-§ ‚Á‚Ä‚¢ ‚é ‚AE •l ‚¦ ‚ç‚ê ‚é ‚ae‚¤‚É‚È ‚Á‚Ä‚« ‚½(Fig. 1)•B •RŽ_‰» •¨ Ž¿‚AE‚µ‚Ä-Ç ‚-'m ‚ç‚ê‚Ä‚¢ ‚é ‚à‚Ì ‚É‚Í,Ž‰-n •« ‚Ì ƒr ƒ^ ƒ~ƒ"E(ƒ¿-ƒg ƒRƒt ƒFƒ• •[ ƒ‹)‚AE •…-n •« ‚Ì ƒrƒ^ ƒ~ ƒ"C(ƒA ƒXƒRƒ‹ ƒrƒ"Ž_)‚ª ‚ ‚é•B ‚³ ‚ç ‚Éˆê •d •€ Ž_'f ‚Ì •Á ‹Ž•Ü‚Å‚ ‚é ƒrƒ^ ƒ~ƒ"A(ƒOE ƒ` ƒm•[ ƒ‹)‚â ƒÀ-ƒJƒ• ƒ` ƒ"‚Ì •RŽ_‰» •« ‚à•L ‚-"F‚ß ‚ç‚ê ‚Ä‚¢ ‚é •B ‚±‚ê ‚ç‚Ì •¬•ª ‚Í,‚¢ ‚¸ ‚ê ‚àOE'•N‚ðˆÛŽN‚ðˆÛŽ•‚· ‚邽‚ß ‚É•K-v ‚È •u •RŽ_‰»ƒrƒ^ ƒ~ƒ"•v ‚Å ‚ ‚è,ŽÀ •Û‚É"®-¬•d ‰» ‚â ƒKƒ"‚Ì-\-h‚É-L OEø‚Å‚ ‚é ‚± ‚AE ‚ª •ñ •• ‚³ ‚ê ‚Ä‚¢ ‚é•Bˆê •û,‚± ‚ê ‚ç‚Ì •RŽ_‰»ƒrƒ^ ƒ~ƒ"‚É'Î ‚µ ‚Ä,ƒr ƒ^ ƒ~ƒ"‚AE‚µ‚Ä‚Ì ‹@"\ ‚Í ‚AE‚-‚É‚È‚¢ ‚ª,•‚ ‚¢•RŽ_‰»-Í‚ðŽ¦ ‚· "V'R•¬•ª ‚ª OE© •o ‚³ ‚ê,‚» ‚Ì • ¶-• OEø ‰Ê ‚ª '•-Ú ‚³ ‚ê ‚Ä‚¢ ‚é•B‚· ‚È‚í ‚¿,-ì •Ø,‰Ê•¨,"¤-Þ ' † ‚Ì ƒt ƒ‰ ƒ{ƒmƒCƒh ‚â ƒCƒ\ ƒt ƒ‰ ƒ{ƒm ƒC ƒh ‚ð ‚Í ‚ ¶‚ß ‚AE ‚· ‚é ƒ| ƒŠƒt ƒFƒm•[ ƒ‹-Þ,