Seria a Doença de Parkinson fator protetor da enxaqueca?

Abstract

Objective. Make a review on the involvement of dopaminergic pathways in migraine and discuss the hypothesis that Parkinson's disease (PD), causing degeneration of dopaminergic pathways, could serve as a protective factor for Migraine. Method. We performed a Non-systematic review of articles using the keywords: "dopamine", "migraine" and "Parkinson Disease". Articles with the combination of these keywords in the title were preferred. We used to search the PubMed and Lilacs database. Results. We choose 32 original articles, 6 review articles and one manual. Conclusion. Migraine is characterized by a state of increased dopaminergic activity in the central nervous system (CNS) with evidence that Parkinson's disease, by causing degeneration of these pathways, among other changes in the central nervous system, serve as a protective factor for migraine.