Association between disruption of circadian activity rhythms and obesity

Abstract

This cross-sectional study aimed to elucidate the association between disruption of circadian activity rhythms and obesity-related indices. This study included 69 older participants (male, n = 36; female, n = 33), and disruption of circadian activity rhythms in daily life was assessed using the cosinor method based on physical activity data. The daily physical activity data were fitted to a cosine curve to estimate the peak phase (acrophase), and the difference in the peak phase (time) for each day was determined. The standard deviation (SD) of the mean peak phase differences over 6 days was obtained. The higher the SD value, the more disturbed the circadian rhythm of activity. Based on the calculated values, the samples were divided into tertiles (small, medium, and large). A significant positive correlation was found between Log SD and body fat percentage on the disruption of circadian activity rhythms and obesity-related indices. In addition, positive associations were observed among body mass, body mass index, and Log SD. However, these associations were not observed in women. These results suggest that disruption of circadian activity rhythms is associated with obesity-related indices and may differ according to sex.