Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons

Abstract

Background: Ca2+/calcineurin-dependent transcription factor NFAT regulates many neuronal functions. Results: Depolarization/Ca2+ influx-induced activation and nuclear translocation are markedly faster and stronger for NFATc3 than NFATc4 in neurons, which is determined in part by SP-containing regions of NFATc3 and NFATc4. Conclusion: Activation of NFATc3 and NFATc4 is distinctly regulated in neurons. Significance: The distinct regulation of NFATc3 and NFATc4 may underlie isoform-specific NFAT functions in neurons. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.