IgA nephropathy in non-cirrhotic portal hypertension

Abstract

Renal glomerular changes are a well recognised complication of cirrhosis1-3 and are frequently characterised by mesangial IgA deposition.4-8 We report a patient with noncirrhotic portal hypertension who developed IgA nephropathy and a nephrotic syndrome with renal histological changes classically associated with cirrhosis. Splenectomy with resection of a splenic artery aneurysm resulted in remission of the nephrotic syndrome. This case illustrates the factors which contribute to the pathogenesis of IgA nephropathy in liver disease.