Autoimmune disease

Abstract

Peroxisome proliferator-activated receptors (PPARs) are members for the nuclear hormone receptors superfamily of ligand-activated transcriptional factors. PPARs have diverse function for keeping physiology of the human body, such as fatty acid regulation. In particular, PPAR-alpha and -gamma, have anti-inflammatory function and play an important role in immune system. With these ligands, we can suppress inflammation and regulate abnormal immune reaction in variety of immunocompetent cells and organs. In this review, we show the utility of PPARs ligands in models for autoimmune disease, and also examine that these ligands have the possibility of application for useful treatments of human autoimmune diseases.