LG-57LOW GRADE GLIOMA (LGG) IN ADOLESCENTS. EXPERIENCE FROM ONE CENTER

Abstract

Background: Adolescent LGG accounts for about 5.5% of all LGG in children. AIM: Analysis of LGG in adolescents. MATERIAL AND Methods: Among 1183 children with LGG treated between 1998-2014 139 (11.7%) were adolescents. Analysis included: age, sex, tumor location, LGG subtype, treatment, outcome. Results: Median age was 16.5 years. Most common location was supratentorial 63%, 3 patients had disseminated disease. 62%underwent complete, 15.8%subtotal/partial resections, 20,9 % biopsy. One patient had radiological diagnosis only. There were 106 patients with astrocytoma I, 32 patients with astrocytoma II. 121 patients were managed with clinical and radiological follow-up in our center until 18 years of age. After that they were referred to adult's centers and were lost to follow-up. Eighteen patients at some point in time received further treatment in our department.Amongthem 14 tumors were supratentorial and 1 infratentorial, 3 had disseminated disease. Most patients had pilocytic astrocytoma (66,6%). All patients had primary partial resection or biopsy. Treatment included chemotherapy (10) radiotherapy (1), both Methods (7) patients. In 11 patients chemotherapy was administered at the time of diagnosis. The rest of the patients were treated at tumor progression (7pts). Median time to progression was 8 months. Out of 18 patients 17 are alive with median follow-up 9.5 years. 5 yr EFS and OS is 60%, 94% respectively. Conclusions: Adolescents with LGG seem to have favorable outcome. Since their current status is unknown evaluation of their long term prognosis is not possible. Cooperation with adult's care centers is necessary.