Diastereoselective fluorination of chiral imide enolates using n-fluoro-o-benzenedisulfonimide (nfobs)

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Abstract

α-Fluoro acids (78-90% ee) and β-fluoro alcohols (89->95%ee) of well defined stereochemistry are prepared via the diastereoselective fluorination of chiral imide enolates with NFOBS (3). © 1992.

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Davis, F. A., & Han, W. (1992). Diastereoselective fluorination of chiral imide enolates using n-fluoro-o-benzenedisulfonimide (nfobs). Tetrahedron Letters, 33(9), 1153–1156. https://doi.org/10.1016/S0040-4039(00)91883-5

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