Clinical Implications of Persistent Organic Pollutants ‐ Epigenetic Mechanisms

Abstract

An epigenetic influence on many chronic and metabolic diseases is now well-established, in some cases with a larger effect on disease risk and susceptibility than many well-established risk factors. Additionally, the evidence base for the role of persistent organic pollutants in many of these same diseases has grown considerably, and it appears that the toxic effects of these substances are mediated in part via epigenetic mechanisms, particularly during critical periods of development. Here we review the associations between these long-lasting toxins and today's highly prevalent diseases, the epigenetic pathways, as well as suggested interventions to mitigate their harm.