One pot BF3.MeCN catalyzed solvent free synthesis of 3,4-dihydropyrimidine-2-one analogues

Abstract

One-pot solvent free three components coupling of aryl aldehydes, β-dicarbonyl compounds, urea or thiourea was performed to afford corresponding 3,4-dihydropyrimidine-2-ones and their sulfur analogs 3,4-dihydro-pyrimidine-2-thiones. It is the first report of BF3.ACN catalyzed the solvent-free synthesis of pyrimidone analogs.