Skip to content

Genome remodelling in a basal-like breast cancer metastasis and xenograft

914Citations
Citations of this article
1.0kReaders
Mendeley users who have this article in their library.

This artice is free to access.

Abstract

Massively parallel DNA sequencing technologies provide an unprecedented ability to screen entire genomes for genetic changes associated with tumour progression. Here we describe the genomic analyses of four DNA samples from an African-American patient with basal-like breast cancer: peripheral blood, the primary tumour, a brain metastasis and a xenograft derived from the primary tumour. The metastasis contained two de novo mutations and a large deletion not present in the primary tumour, and was significantly enriched for 20 shared mutations. The xenograft retained all primary tumour mutations and displayed a mutation enrichment pattern that resembled the metastasis. Two overlapping large deletions, encompassing CTNNA1, were present in all three tumour samples. The differential mutation frequencies and structural variation patterns in metastasis and xenograft compared with the primary tumour indicate that secondary tumours may arise from a minority of cells within the primary tumour. © 2010 Macmillan Publishers Limited. All rights reserved.

Cite

CITATION STYLE

APA

Ding, L., Ellis, M. J., Li, S., Larson, D. E., Chen, K., Wallis, J. W., … Mardis, E. R. (2010). Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature, 464(7291), 999–1005. https://doi.org/10.1038/nature08989

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free