THE EFFECT OF THE MOLECULAR WEIGHT OF HYALURONIC ACID ON THE RHEOLOGICAL AND TRIBOLOGICAL PROPERTIES OF THE BASE FOR ARTIFICIAL SYNOVIAL FLUID PREPARATIONS

Abstract

The synovial fluid is responsible for adequately lubricating, moisturizing, and nutritional human joints. This liquid should have appropriate viscoelastic properties and ensure a low coefficient of friction in biotribological systems. Many artificial synovial fluid preparations used in viscosupplementation treatments are based on hyaluronic acid. This work aimed to evaluate the influence of molecular weight on the functional properties of solutions based on hyaluronic acid. 1% solutions based on hyaluronic acid with five different molecular weights from 50,000 Da to 2 MDa were made. Rheological (viscosity, viscoelasticity), tribological (coefficient of friction, wear assessment), and wettability tests were carried out. Significant differences were observed in the rheological tests, where the viscosity strictly depends on the molecular weight of the hyaluronic acid. It has been shown that the molecular weight of HA has little effect on the coefficient of friction. On the other hand, the differences in the tribological wear are much more significant. The molecular weight of biopolymers is one of the essential parameters in developing new artificial synovial fluids. Using a higher molecular weight of hyaluronic acid increases viscosity and wettability, resulting in less tribological wear.