Analysis of anti-infection therapeutic schedule analysis for neonatal Streptococcus agalactiae meningitis and discussion on the indications for drug withdrawal

Abstract

The clinical manifestations of neonatal GBS meningitis are as follows: non-specificity, long hospital stay, easy to cause neurological complications, and sequelae. Clinical pharmacist participated in the anti-infective treatment of a neonatal Streptococcus agalactiae meningitis whose cerebrospinal fluid was still abnormal when the drug was stopped. According to the PK/PD characteristics of antibacterial drugs, the permeability of the blood-brain barrier, and the adjustment of the antibiotic dose, the reasons for the decrease in the number of cerebrospinal fluid cells after vancomycin treatment were analyzed. Clinical pharmacists also analyzed the efficacy of linezolid in the treatment of neonatal bacterial meningitis, and discussed the indications for stopping medication when the cerebrospinal fluid is abnormal, so as to improve the safety and effectiveness of antibiotics in the treatment of neonatal bacterial meningitis.