Toll-like receptors as a target of food-derived anti-inflammatory compounds

Abstract

Background: Vegetable-rich diets are associated with the reduced risk of inflammatory diseases. Results: Iberin, an isothiocyanate compound from cabbage, targeted TLRs, disrupted TLR dimerization, and inhibited the inflammatory responses. Conclusion: The TLR dimerization step is a target of food-derived anti-inflammatory compounds. Significance: These findings extend our understanding of how isothiocyanates show their medical benefits as anti-inflammatory food components.