Effect of Silver Nanoparticles On Energy Metabolism In Selected Tissues Of Aeromonas Hydrophila Infected Indian Major Carp, Catla Catla

Abstract

The aim of the present study was to evaluate the effect of silver nanoparticles (AgNPs) on energy metabolic enzymes in selected tissues of Aeromonas hydrophila injected Indian major carp, Catla catla. Fishes exposed to 1/10 th concentration of AgNPs (100 µg/l) did not alter lipid peroxidation levels as compared to 1/5 th concentration of AgNPs in gills, liver and kidney of fishes. Therefore, 1/10 th concentration of AgNPs was selected for subsequent experiments. Significant decrease in the activity levels of succinate dehydrogenase with a significant increase in the activity levels of glucose-6-phosphate dehydrogenase and lactate dehydrogenase in gills, liver and kidney of A. hydrophila infested fishes as compared to controls over a 14-day exposure period. On the other hand, exposure of bacterial infected fishes to 1/10 th concentration of AgNPs reversed the activity levels of enzymes in selected tissues as compared to bacterial infected fishes. However, no significant changes were observed in the activity levels of selected enzymes in tissues of fishes exposed to 1/10 th concentration of AgNPs alone over controls. From the results, it can be concluded that A. hydrophila injection leads to prevalence of anaerobic conditions to meet the demand of energy in tissues whereas AgNPs through their antibacterial properties mitigate A. hydrophila induced changes in oxidative metabolism thereby energy crisis in tissues of fishes.