Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

Abstract

Ishizawa et al. report that hyperactivating the mitochondrial caseinolytic protease P (ClpP)degrades respiratory chain proteins, disrupts mitochondrial function, and selectively kills cancer cells, regardless of p53 status. They identify imipridones as hyperactivators of ClpP and show their anti-tumor activity.