Efficacy of citalopram in the prevention of recurrent depression in elderly patients: Placebo-controlled study of maintenance therapy

Abstract

Background: The highly recurrent nature of major depression in the young and the elderly warrants long-term antidepressant treatment. Aims: To compare the prophylactic efficacy of citalopram and placebo in elderly patients; to evaluate long-term tolerability of citalopram. Method: Out-patients, ≥65 years, with unipolar major depression (DSM-IV: 296.2 x or 296.3 x) and Montgomery-Åsberg Depression Rating Scale score ≥22 were treated with citalopram 20-40 mg for 8 weeks. Responders continued on their final fixed dose of citalopram for 16 weeks before randomisation to double-blind treatment with citalopram or placebo for at least 48 weeks. Results: Nineteen of the 60 patients using citalopram v. 41 of the 61 patients using placebo had recurrence. Time to recurrence was significantly different between citalopram- and placebo-patients, in favour of citalopram (log-rank test, P < 0.0001). Long-term treatment was well tolerated. Conclusions: Long-term treatment with citalopram is effective in preventing recurrence of depression in the elderly and is well tolerated.