Biochemical studies on the hepatoprotective effect of Curcuma longa on some glycolytic enzymes in mice

Abstract

This study aims to clarify the induction of the "Crabtree consequence" in liver cells through measuring certain biochemical parameters in livers of Schistosoma mansoni infected mice. The liver is one of most significant target for toxic substances. and represents the main site for detoxication in the organism. The curative effect of oil extract of Curcuma longa (C. longa) were tested and compared to praziquantel (PZQ) as the effective drug against all schistosome species occurring in man. Measurement of protein, glucose, glucose-6-phopsphatase (G-6-Pase), AMP-deaminase, adensoine deaminase, urea concentration, pyravate kinase (PK), phosphoenol pyruvate carboxykinase (PEPCK) and PK/PEPCK ratio were performed. In addition worm burden and ova count in mice infected with S. mansoni were elucidated. The result showed that C. longa normalized the concentration of protein, glucose, AMP-deaminase and adenosine deaminase which were changed by infection. Moreover it lowered pyruvate kinase (PK) level, which was elevated in infected mice while PZQ-treatment induced more elevation of this enzyme. Regarding the parasitological parameters, PZQ was more effective in lowering worm burden while C. longa extract was more potent in reducing egg count. © 2006 Asian Network for Scientific Information.