In Vitro and In Vivo activities of the novel ketolide RBx 14255 against Clostridium difficile

Abstract

The MIC90 of RBx 14255, a novel ketolide, against Clostridium difficile was 4 |uig/ml (MIC range, 0.125 to 8 |uig/ml), and this drug was found to be more potent than comparator drugs. An in vitro time-kill kinetics study of RBx 14255 showed time-dependent bacterial killing for C. difficile. Furthermore, in the hamster model of C. difficile infection, RBx 14255 demonstrated greater efficacy than metronidazole and vancomycin, making it a promising candidate for C. difficile treatment. Copyright © 2012, American Society for Microbiology. All Rights Reserved.